POs-Ca™ < Food Ingredient>

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Potato starch is a typical glucose polymer that contains ester-linked phosphate groups. Phosphoryl oligosaccharides (phosphoryl maltooligosaccharides) are produced through potato starch enzymatic hydrolysis. POs-Ca is produced as a calcium salt of phosphoryl oligosaccharides.
POs-Ca is composed of maltooligosaccharides in which at least one or two phosphate groups are bound with a calcium ion (maltotriose to maltooctaose).

< Major components of POs-Ca >

High solubillty in water
POs-Ca, a food ingredient, is a highly water-soluble calcium substance. It dissolves easily even in water with high calcium concentration.
With its relatively high calcium level (5%) and extremely high water solubility, POs-Ca serves as an ingredient in food, beverages, supplements, and other oral products.

POs-Ca®(Phosphoryl Oligosaccharides of Calcium) containing 5% (w/w) calcium provides soluble calcium in saliva, and effectively enhances the remineralization and recrystallization of enamel lesions. Fluoride ions with POs-Ca are possibly effective against early caries lesion.

POs-Ca is applicable to caries prevention
POs-Ca has many merits in the application of caries prevention.

1. Highly soluble calcium from POs-Ca in saliva
2. Not be assimilated by mutans streptococci
3. Avoiding the fall of plaque pH
4. Promoting 3Rs for caries prevention
5. 3Rs = Remineralization, Recrystallization, Rehardening

Clinical study
Each subject chewed 2 pieces of one of the following 3 types of chewing gum for 20 minutes at a time, 3 times daily for 14 consecutive days.
(1) : Sugarless chewing gum (2) : (1) + 2.5% POs-Ca (3) : (2) + fluoride (~1 ppm in saliva)

Remineralization (Ref.1,2)
POs-Ca-derived calcium in the saliva promoted the remineralization of early-stage caries lesion. Addition of fluoride promoted tooth remineralization even further. (See figure A)

Recrystallization (Ref.1,2)
The study was conducted at SPring-8, one of the world's biggest synchrotron radiation facilities. The results of the study demonstrated that the calcium deposited in the enamel of the tooth in the course of remineralization had the same ordered crystal structure as that of the healthy tooth. In other words, POs-Ca was restored the healthy tooth microstructure. Addition of fluoride promoted even further. (See figure B)

Rehardening (Ref.3)
Early-stage caries causes mineral loss and softening of the affected site of a tooth surface. The recovery of tooth hardness was shown to be enhanced by POs-Ca alone and even further by POs-Ca plus fluoride. (See figure C)

POs-Ca's calcium can be soluble with fluoride
POs-Ca can also be used with fluoride, which is beneficial in preventing caries. In the presence of fluoride ions, conventional calcium (e.g. calcium chloride) forms an insoluble salt. However, POs-Ca's calcium is kept soluble in saliva in the presence of fluoride (Left figure), and releases calcium in the enamel subsurface. In the presence of 0.5 to 1.0-ppm fluoride, which is comparable to fluoridated water, POs-Ca showed the best remineralization effect in an in vitro study (Right figure).

The product of chewing gum which containing POs-Ca is authorized as a Foods for Specified Health Uses (FOSHU) in Japan
FOSHU refers to foods that contain an ingredient with a beneficial health function and are officially approved to claim its physiological effects on the human body in Japan.

Specifications

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