POs-Ca™ < Cosmetic Ingredient >

POs-Ca

  • Phosphoryl Oligosaacharides of Calcium
  • POs-Ca,a calcium salt of phosphoryl oligosaccharides made from potato starch, is a derivative of maltooligosaccharides and is characterized as a highly water-soluble calcium carrier.

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    Structure and Manufacturing ProcessCharacteristicsSkin-CareScalp-CareSpecificationsContact Us

    Structure and Manufacturing Process

  • Potato starch is a glucose po contains ester-linked phosphate groups. Phosphoryl oligosaccharides (phosphoryl maltooligosaccharides) are produced through enzymatic hydrolysis of potato starch, POs-Ca is produced as a calcium salt of phosphoryl oligosaccharides.
  • POs-Ca comprises maltooligosactaosecharides (maltotriose to maltoctaose) in which at least one or two phosphate groups are bound to a calcium ion.

    • Characteristics

  • ●High water solubility; dissolves up to 70%
  • ●Soluble in 20% or less ethanol aolution
  • ●Weak electrolyte

    • Skin-Care

    [ 1st barrier ]

  • Promotion of gene expression for stratum corneum conditioning and skin hydration
  • Expression levels of genes in normal human epidermal kerationocyter (NHEKs) cultured with/without 0.1% POs-Ca for 144 hours was analyzed by HPTLC.After visualizing the spots in the HPTLC plate, the amounts of ceramides and cholesterol were quantitatively determined using a densitometer (Fig.B)

  • Promotion of intercellular lipid production
  • intercellular lipid in NHEKs cultured with/without 0.1% POs-Ca for 144 hours was analyzed by HPTLC. After visualizing the spots in the HPTLC plate, the amounts of ceramides and cholesterol were quantitatively determined using a densitometer (Fig. C).

  • Promotion of cell differentiation
  • Production of involucrin protein, a keratinocyte differentiation marker, was promoted in NHEKs cultured for 144 hours in the presence of 0.1% POs-Ca compared with that in the absence of POs-Ca (Fig. C).

    • [ 2nd barrier ]

  • Enhancement of tight junction (TJ) formation
  • NHEKs were cultured with 0.1% POs-Ca to determine the following:
  • Expression levels of genes for TJ related proteins, occludin and claudin-4 in NHEKs cultured for 144 hours ( Fig. B).
  • lmmunostaining of occludin and claudin-4 in NHEKs cultured for 144 hours (Fig. B)
  • Continuous honeycomb localization of TJ proteins at cell borders was observed only in POS-Ca treated cells.

  • Percutaneous administration of POs-Ca is significan effective for inproving skin hydration,barrier function,stratum corneum condition, and skin texture.

    • Scalp-Care

  • Genes related to angiogenesis (growth of new blood vessele), anti-apoptosis of DPCs, and extracellular matrix were upregulated by POs-Ca.

    • [ Proliferation of follicle dermal papilla cells ]

  • PDCs were plated on a 96-well plate, incubated at 37℃ for 3 days, and subsequently analyzed by spectrophotometer.
  • PDCs were treated in media with POs-Ca/Cacl2, and the number of cells in each group was assayed(p<0.05, vs. control)

  • Proliferation of DPCs was enhanced more effectively by POs-Ca than by conventional calcium.

    • Specifications

    Specifications

    For further information please contact us.

    Name
    Trade name POs-Ca
    INCI name Calcium Phosphoryl Oligosaccharides
    Chinese INCI name 磷酰基寡糖钙

    Other Information
    Cas No. 1124316-47-7
    Certification ISO 90001

    Contact Us
    for enquiries, contact Global Sales Department, Technical Sales Division, Glico Nutrition Co., Ltd.
    4-6-5, Utajima, Nishiyodogawa-ku, Osaka 555-8502 Japan
    FAX: +81 6-6477-8673
    E-MAIL: g-ingredients@glico.com
    * When you contact us, please let us know your name, company and country in the message.